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Building the Next Generation of Building Freaks!

• Promotes Muscle Cell Hyperplasia
• Promotes Muscle Activation
• GHRP-2 Hexapeptide
• IGFBP-3 Inhibitor
• Enhances Protein Synthesis
• Enhances Amino Acid Uptake
• Improves Sleep Quality
• Increases Fat Burning Metabolism
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• Building the Next Generation of Bodybuilding Freaks!

  The development of HEXAGHEN introduced muscle building to a new frontier in GH science. The MuscleMeds research and development team has made the leap into a new territory of muscle cell hyperplasia and muscle activation through the utilization of a unique combination of highly specialized actives, which includes a scientifically validated amino Hexapeptide. GHRP-2 Amino Hexapeptide and unique compounds that have the ability to help inhibit IGFBP-3. When taken at night, these compounds can help induce a deep anabolic sleep to accelerate muscle growth and stimulate fat burning metabolism.

  These advanced compounds are administered in a patent pending FastSorb tablet delivery. The FastSorb tablet provides oral mucosal delivery, which allows for these compounds to be better absorbed – thereby preserving their activity as an anabolic activator. HEXAGHEN is still an exciting muscle building breakthrough even after four years on the market.

  Pharmadynamic IGF-1 Optimizer

  The development of HEXAGHEN, a unique orally effective IGF-1 activator, is going to help breed a new generation of top-level bodybuilders. Science shows that the benefits of improved GH and IGF-1 can be a “holy grail” to muscular growth. They pose highly anabolic actions and are critical mediators of muscle growth as they have the ability to help stimulate both the differentiation and proliferation of myoblasts (muscle cells). In general terminology, this means they have the unique ability to benefit not only the size but also the number of muscle cells. IGF-1 produced in the body also enhances muscle growth by increasing amino acid uptake and protein synthesis.

  Through the development of HEXAGHEN, you can experience the anabolic promoting effects by boosting your IGF-1 levels. HEXAGHEN’s threshold IGF-1 output can help promote anabolic muscle cell hyperplasia and stimulate muscle cell growth.

  HEXAGHEN’s efficacy is made possible through the utilization of a unique combination of highly specialized actives, which include:  an amino Hexapeptide, GHRP-2 Amino Hexapeptide and the botanical based compounds cis -4, 17(20)-pregnadiene-3,16-dione, and trans-4, 17(20)-pregnadiene-3,16-dione, administered in a unique and FastSorb tablet delivery.

  Active Compounds:

  HEXAGHEN FastSorb tablets belong to a new class of orally effective IGF-1 (Insulin-Like Growth Factor-1) stimulating compounds. HEXAGHEN utilizes a FastSorb delivery system for better absorption and bioavailability.

  HEXAGHEN FastSorb tablets for oral administration contain IGF-1 Optimizing synergistic compounds:

  • GHRP-2 Amino Hexapeptide
  • Botanical-based cis -4 and trans-4, 17(20)-pregnadiene-3,16-dione

  The Science of Insulin-Like Growth Factor-1 (IGF-1) In Humans

  IGF-1 produced in the body possess some unique anabolic characteristics and is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and multiplication. Attention was first turned to IGF-1 when scientists researching growth hormone (GH) discovered that GH’s influence on IGF-1 production was a key factor responsible for the anabolic effects associated with growth hormone administration and natural elevation in the body. In fact, while endogenous GH has direct fat burning effects as it metabolizes stored body fat, its muscle building effects are primarily attributed to its effects on increasing IGF-1 levels. Therefore, IGF-1 and not necessarily GH itself that can directly mediates muscle cell hyperplasia and muscle growth at the cellular level. IGF-1 is thought to be the critical mediator as it stimulates both the differentiation and proliferation of myoblasts (muscle cells), resulting in muscle growth. IGF-1 also enhances muscle growth by increasing amino acid uptake and protein synthesis.

  IGF-1 is an important peptide hormone that is involved in regulating growth and development of muscle tissue. Its primary action is mediated by binding to specific IGF-1 receptors present on many cell types in many tissues. The free form IGF-1 fraction is highly bio-active in comparison to the IGF-1 bound to IGF Binding Proteins (IGFBPs). IGF-1 is the principal hormonal mediator of growth in the body. In the cascade of biochemical events leading to a surge in IGF-1 production and levels, HEXAGHEN stimulated growth hormone is metabolized by the liver and potentiates the synthesis and secretion of IGF-1.

  Muscle tissue has an abundance of IGF-1 receptors. When serum IGF-1 binds to these receptor sites on muscle tissue, it can stimulate the following anabolic actions and growth processes in humans, including increasing the number and size of muscle cells:

  • REGULATES CELL GROWTH AND DEVELOPMENT.
  • REGULATES CELLULAR DNA SYNTHESIS.
  • MEDIATES MUSCLE CELL HYPERPLASIA AND MUSCLE FIBER DEVELOPMENT INITIATION AND MATURATION.
  • STIMULATES THE GROWTH AND SIZE OF MUSCLE CELLS.
  • STIMULATES GLUCOSE UPTAKE BY MYOBLASTS (MUSCLE PRECURSOR CELLS), WHICH FUELS THEIR GROWTH AND DEVELOPMENT INTO MUSCLE FIBER CELLS.
  • INCREASES MUSCLE CELL UPTAKE OF AMINO ACIDS, USED AS BUILDING BLOCKS OF MUSCLE PROTEIN MOLECULES.
  • INCREASES NITROGEN RETENTION AND A GREATER FOOD CONVERSION EFFICIENCY.
  • REDUCES NITROGEN EXCRETION.
  • IMPROVES WOUND HEALING.
  • STIMULATES MUSCLE PROTEIN SYNTHESIS.
  • PREFERENTIALLY STIMULATES THE GROWTH OF LEAN TISSUE.
  • STIMULATES MITOGENIC (CELL REPLICATION) ACTIVITIES THAT LEAD TO AN INCREASED NUMBER OF MUSCLE CELLS IN THE BODY.
  • VITAL FOR MUSCLE REPAIR AND REGENERATION.
  • IMPROVE BODY COMPOSITION, HELPING TO DECREASE BODY FAT MASS AND A INCREASE IN LEAN BODY MASS.

  The relationship within the endocrine/IGF-1 axis is a complex system. Scientists have recently identified other factors that play a critical role in affecting IGF-1 levels. IGF-1 is bound to one of several insulin-like growth factor binding proteins (IGFBP). IGFBP-3, the most abundant protein, accounts for as much as 80% of all IGF-1 binding. Research has demonstrated that reducing IGF-1 binding proteins and maintaining higher levels of free IGF-1 is correlated to improved anabolic effects and muscle development.

  As reported in independent research journals, thyroid function is also associated with enhancing IGF-1 bio-active tissue levels and further increasing the rate of protein synthesis. Therefore, as IGF-1 levels are increased, a series of negative feedback controls involving the thyroid endocrine axis are triggered to keep IGF-1 levels within a narrow physiological range; not too high and not too low.

  Research and Development

  By examining the relationship between GH, IGF-1 production, IGF-1 levels, free IGF-1, IGFBP and thyroid function, MuscleMeds researchers addressed this correlation between IGF-1 production and bio-effectiveness related to thyroid stimulation. HEXAGHEN’s synergistic thyroid involvement is designed to help sustain higher total and free IGF-1 levels for longer periods of time, thereby extending the overall desired IGF-1 anabolic effects.

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  The muscle building effects of IGF-1 have been well known and medically documented for years. But the controlling factors regulating the body’s natural output have challenged researchers. The development of orally effective IGF-1 enhancing compounds has been a global objective of biotechnologists.

  MuscleMeds researchers, in their search for such compounds, found GHRP-2 Amino Hexapeptide. In our research, we noted that due to its long hexapeptide structure, the development of an effective oral dosage form for GHRP-2 Amino Hexapeptide had posed some biotechnical challenges. As with other peptide substances, GHRP-2 Amino Hexapetide is subject to destruction (breakdown) in the gastrointestinal system, which can effect the effectiveness and ability to reach the hypothalamus-pituitary axis. In order to ensure an effective and suitable oral administration of the HEXAGHEN GHRP-2 Amino Hexapeptide, MuscleMeds employed the utilization of their proprietary FastSorb delivery system technology.

  As a result of this researched based product development effort, HEXAGHEN features a unique IGF-1 Optimizing Complex. HEXAGHEN’s novel ingredient composition and proprietary liposomal delivery system is designed to stabilize the bioactives for effective absorption and utilization into the bloodstream. This improves the bioeffectiveness of delivery into the body, to trigger a series of endocrine medicated events: HEXAGHEN stimulates GH and IGF-1 levels and supports thyroid function for greater effects.

  *THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. MUSCLEMEDS PRODUCTS ARE NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.